Thursday, December 24, 2015

Effect of cell phone-like electromagnetic radiation on primary human thyroid cells

Effect of cell phone-like electromagnetic radiation on primary human thyroid cells


Joel's comments: The exposures in this study were rather low as the maximum SAR was 0.170 W/kg.  The exposures in the three experimental conditions ranged from 895 to 900 Mhz, 80 to 210 μW/cm2 power density, and 0.082 to 0.170 W/kg SAR. 

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Effect of cell phone-like electromagnetic radiation on primary human thyroid cells


Silva V, Hilly O, Strenov Y, Tzabari C, Hauptman Y, Feinmesser R. Effect of cell phone-like electromagnetic radiation on primary human thyroid cells. Int J Radiat Biol. 2015 Dec 21:1-9. [Epub ahead of print]

Abstract

Purpose To evaluate the potential carcinogenic effects of radiofrequency energy (RFE) emitted by cell phones on human thyroid primary cells.

Materials and methods Primary thyroid cell culture was prepared from normal thyroid tissue obtained from patients who underwent surgery at our department. Subconfluent thyroid cells were irradiated under different conditions inside a cell incubator using a device that simulates cell phone-RFE. Proliferation of control and irradiated cells was assessed by the immunohistochemical staining of antigen Kiel clone-67 (Ki-67) and tumor suppressor p53 (p53) expression. DNA ploidy and the stress biomarkers heat shock protein 70 (HSP70) and reactive oxygen species (ROS) was evaluated by fluorescence-activated cell sorting (FACS).

Results Our cells highly expressed thyroglobulin (Tg) and sodium-iodide symporter (NIS) confirming the origin of the tissue. None of the irradiation conditions evaluated here had an effect neither on the proliferation marker Ki-67 nor on p53 expression. DNA ploidy was also not affected by RFE, as well as the expression of the biomarkers HSP70 and ROS.

Conclusion Our conditions of RFE exposure seem to have no potential carcinogenic effect on human thyroid cells. Moreover, common biomarkers usually associated to environmental stress also remained unchanged. We failed to find an association between cell phone-RFE and thyroid cancer. Additional studies are recommended.

Conclusions

We here report that different evaluated RFE exposure conditions have no potential carcinogenic effect on thyroid cells. Proliferation and cellular DNA integrity, two major players in cancer development and progression were not affected in our conditions. Moreover, common biomarkers that are usually associated with environmental stress also remained unchanged after RFE irradiation. Among the limitations of our work we consider that even though measurements of extremely low frequency interference were considerably low, the stray magnetic fields emitted by the instruments used in the study may have had a confounder effect on our results. On the other hand, different conditions of time and frequencies of exposure should be further explored in order to completely cross out a deleterious effect of RFE on thyroid cells. In summary, the increase of both, thyroid cancer and cellular phone use calls the attention to further investigate the potential effects that chronic use of mobile phones might have on the thyroid gland.

http://1.usa.gov/1QKkvx9

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For more studies on wireless radiation and thyroid cancer see http://bit.ly/cellphonethyroid.

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Joel M. Moskowitz, Ph.D., Director
Center for Family and Community Health
School of Public Health
University of California, Berkeley

Electromagnetic Radiation Safety

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